L-buthionine-sulfoximine
WebButhionine sulfoximine (BSO) is a sulfoximine derivative which reduces levels of glutathione and is being investigated as an adjunct with chemotherapy in the treatment of cancer. [1] The compound inhibits gamma-glutamylcysteine synthetase, the enzyme required in the … Web28 jun. 2008 · Abstract. Pharmacological depletion of L-gamma-glutamyl-L-cysteinyl-glycine (GSH) has been implicated in the sensitization of cancer cells to alkylating …
L-buthionine-sulfoximine
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WebThe glutathione (GSH) synthesis inhibitor, buthionine sulfoximine (BSO) was tested for cytotoxicity and thiol depletion in murine and human tumor cells in vitro, and for its antitumor activity and toxicity in vivo. The cell lines used in these studies included murine L-1210 leukemia, human RPMI 8226 myeloma, MCF-7 breast cancer and WiDr colon … WebSafety Data Sheet for L-Methionine Sulfoximine 104309. Material Safety Data Sheet or SDS for L-Methionine Sulfoximine 104309 from Merck for download or viewing in the browser. …
WebL-Buthionine-(S,R)-sulfoximine is a cell-permeable, potent, fast acting and irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. The … WebCAS: 83730-53-4 MDL: MFCD00067000 L-Buthionine-sulfoximine (BSO) induces oxidative stress in cells by irreversibly inhibiting γ-glutamylcysteine synthetase, an essential …
WebATP, adenosine triphosphate; BSO, L-buthionine sulfoximine; COX1, cytochrome c oxidase subunit 1; Fe-S, iron-sulfur; FXN, frataxin; GSH, glutathione; mtDNA, mitochondrial DNA; … WebL-Buthionine sulfoximine: SMILES: N[[email protected]](C(O)=O)CCS(CCCC)(=O)=N: Storage: Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is …
Webl-Buthionine sulfoximine C8H18N2O3S CID 119565 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, …
WebPreparing Stock Solutions for L-Buthionine sulfoximine. The following data is based on the product molecular weight 222.3.Batch specific molecular weights may vary from batch to … sift share priceWeb11 jan. 2024 · 丁硫氨酸-亚砜亚胺用途. L-Buthionine- (S,R)-sulfoximine 是一种具有细胞渗透性的、有效的、快速起效的、不可逆的 G-谷氨酸半胱氨酸合成酶 (γ-glutamylcysteine … sift searchWeb27 aug. 2024 · Abstract. l -Buthionine sulfoximine ( l -BSO) is an adjuvant drug that is reported to increase the sensitivity of cancer cells to neoplastic agents. Dendrimers are … sifts definitionWeb5 mrt. 2024 · The co-treatment with l-buthionine sulfoximine (BSO), which inhibits the production of GSH, enhanced the effect of copper complexes on tumor cell viability and … sifts crossword clueWebThere is no significant metabolism of AAs in wheat germ extract except for alanine transaminase (beta-chloro-l-alanine), aspartate transaminase (aminooxyacetate), and glutamine synthetase (l-methionine sulfoximine), which can be inhibited by the compounds indicated (Endo and Sawasaki, 2006; Morita et al., 2004). sift seattleWebL-Buthionine-(S,R)-sulfoximine is an irreversible inhibitor of gamma-glutamylcysteine synthetase (Ki = 25 µM). It inhibits the proliferation of ZAZ and M14 melanoma cells, as … sifts cupcakeryWebL-Methionine sulfoximine is a potent inhibitor of glutamine sythetase activity, that is widely used as a selection agent for plasmid integration in Chinese hamster ovary (CHO) and … sift screen