WebIn breast cancer cells, DACH1 opposed SIX1 action, via transcriptional repression of common targets, including CCND1 and IL8 (interleukin 8) to inhibit cell proliferation and migration in vitro, as well as tumor growth and metastases in vivo ( Popov et al., 2010; Wu et al., 2008, 2006, 2007, 2003 ). WebINVOLVED IN development of primary female sexual characteristics (ortholog); ASSOCIATED WITH autistic disorder (ortholog); syndromic X-linked intellectual disability Lubs type (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; amphetamine

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WebJustin P. Kumar, in Current Topics in Developmental Biology, 2010 4.3 Dac: A transcription factor in search of a target. While a requirement for dac in eye specification and … WebNotably, a result of the present study was that the cell fate determination factor dachshund family transcription factor 1 (DACH1) was identified as a direct target of miR-200c. Suppression of miR-200c expression in NPC cells increased endogenous DACH1 mRNA and protein levels, which was negatively correlated with miR-200c. shortest human ever recorded

Dachshund (gene) - Wikipedia

WebWe have isolated mammalian homologues of the Drosophila dachshund gene. Two domains of high conservation, one of which contains an alpha-helical, coiled-coil motif, show … Webdachshund (dac) is a gene involved in the development of the arthropod compound eye which also plays a role in leg development. It is activated by the Distal-less (Dll) gene. … WebMay 17, 2024 · Here, we performed transcriptome-wide association studies (TWAS), summary Mendelian randomization, and MetaXcan to identify genes whose expression mediates the genotype effect on the phenotype. Our analyses identified Dachshund homolog 1 (DACH1), a cell-fate determination factor. sanft schläft der tod ard mediathek