Cisplatin adducts
WebDespite intense research efforts, no approved therapy is yet available. Cisplatin is a chemotherapeutic drug but induces acute tissue injury. Oleuropein (OLE) is a major phenolic compound and used as a possible natural antioxidant, antimicrobial, and anticancer agent. ... adducts. The treatment with cisplatin elevated the TOS and 8-OH-dG levels ... WebCisplatin is a major anticancer drug that kills cancer cells by damaging their DNA. Cancer cells cope with the drug by removal of the damages with nucleotide excision repair. We …
Cisplatin adducts
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WebCisplatin (NSC 119875, Cisplatinum, cis-diamminedichloroplatinum II, CDDP, cis DDP, DDP) is an inorganic platinum complex, which is able to inhibit DNA synthesis by … WebThe synthesis and characterisation of novel metal-modified DNA precursors for fuel cell catalyst development are described. Material precursors in the form of metal–DNA …
WebSep 24, 2024 · Cisplatin (CDDP) is the drug of choice against different types of cancer. However, tumor cells can acquire resistance to the damage caused by cisplatin, … WebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying novel biomarkers to improve the diagnosis and treatment of NSCLC is important. ... DDP binds to DNA and forms DNA-platinum adducts, which disrupt DNA synthesis and ...
WebSep 5, 2011 · The recognition of inter- and intra-strand DNA adducts and the consequent generation of an apoptotic signal is often impaired in cisplatin-resistant cancer cells … WebCisplatin adducts are Guanine-Guanine (GG) DNA intrastrand cross links caused by the chemical compound Cisplatin. Cisplatin is used as a chemotherapy agent that contains …
WebJan 1, 2001 · Pt adducts on DNA extracted from cells that had been treated with cisplatin were less immunoreactive than DNA treated with cisplatin in vitro, but after heating the immunoreactivity increased such that 50% inhibition in the assay was caused by 2 …
WebJul 1, 2001 · Cisplatin is a widely used chemotherapeutic agent. It reacts with nucleophilic bases in DNA and forms 1,2-d(ApG), 1,2-d(GpG) and 1,3-d(GpTpG) intrastrand … great lakes ice coverage 2021WebApr 11, 2024 · HIGHLIGHTS who: Umit Aliyaskarova from the Universitu00e9 Nazarbayev University have published the paper: NEIL3-mediated proteasomal degradation facilitates the repair of cisplatin-induced DNA damage in human cells, in the Journal: Scientific … Neil3-mediated proteasomal degradation facilitates the repair of cisplatin-induced dna … great lakes ice coverage wattsWebThese covalent adducts are formed by linking the 3, 4 ( pyrone) or 4', 5’ ( furan) edge of psoralen to the 5, 6 double bond of thymine. Psoralens can form two types of monoadducts and one diadduct (an interstrand crosslink) with thymine. [10] These adducts result in local distortions to DNA at the site of intercalation. great lakes hyundai ohioWebCisplatin is administered to cancer patients intravenously as a sterile saline solution (that is, containing salt—specifically, sodium chloride). Once cisplatin is in the … great lakes ice breakersWebCisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck … great lakes ice cover historyWebThis mixture is heated from 20^ {\circ} \mathrm {C} 20∘C to 200^ {\circ} \mathrm {C} 200∘C while flowing through a tube in which the pressure is maintained at 150 kPa. Determine the heat transfer to the mixture per unit mass of the mixture. Verified answer. physics. A 32.0-\Omega 32.0−Ω resistance coil uses 375 \mathrm {~W} 375 W of power. great lakes hyundai incWebThe kinetics of bifunctional cisplatin adduct formation were studied with DNA in vitro and in cultured Chinese hamster ovary (CHO) cells. Prior to adduct measurements with AAS in … float shifting